Functional analysis of structural variants in single cells using Strand-seq
). This suggests a potential differentiation block at the progenitor stage as a result of 6q-CT and, more generally, that 6q-CT cells bear a distinctive molecular phenotype as a result of the chromothriptic rearrangements., Uniform manifold approximation and projection of scRNA-seq data showing ten unsupervised clusters in T-ALL_P1., Overlay of gene set-derived cell-type annotation and inferred lineage trajectory onto this UMAP.
Having identified c-Myb pathway activation as a consequence of 6q-CT in TALL_P1, we hypothesized this molecular phenotype could guide drug targeting in cell culture. We selectedas a suitable candidate for targeting this subclone because this c-Myb target was inferred by scNOVA to be highly upregulated in 6q-CT cells (Fig.
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