This week in Nature: Pump, rest, leak, repeat – ultraslow mode-switching governs proton pumping in mammalian synaptic vesicles. Browse the full issue:
The cover illustration shows vacuolar-type adenosine triphosphatases on a synaptic vesicle from a nerve cell in the mammalian brain. V-ATPases pump protons across cellular membranes, and in neurons this process is essential for loading neurotransmitters into synaptic vesicles. In this week’s issue,shed light on V-ATPase dynamics in single native synaptic vesicles.
Cover image: C. Kutzner, H. Grubmüller and R. Jahn/Max Planck Institute for Multidisciplinary Sciences; Jens Carstensen/University of Copenhagen
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