A new study reveals widespread resistance of a major bacterial pathogen to the active ingredients in cleaning agents commonly used in hospitals and homes.
The American Chemical Society Infectious Diseases published the research, led by chemists at Emory University. It demonstrates the surprising level of resistance to cleaning agents of multidrug-resistant, including a novel compound developed at Emory in collaboration with Villanova University. The researchers describe how these biocides work differently than most disinfectants currently in use.
"Resistance of pathogens to cleaning agents is an area that's often overlooked," Vargas-Cuebas says,"but it's an important area of study, especially with the rise in antibiotic-resistant pathogens worldwide."Quaternary ammonium compounds, or QACs, are active ingredients commonly seen in household and hospital cleaners, including some disinfectant sprays and liquids, antibacterial sanitizing wipes and soaps.
The results showed that all 20 strains were at least partially resistant to QACs -- the common active ingredient in most front-line cleaning agents -- and 80% of the strains were fully resistant to QACs. They showed that this same mechanism underlies the effectiveness of two commercial antiseptics: octenidine, more commonly used in Europe as a hospital antiseptic, and chlorhexidine, a common ingredient in mouthwashes.
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