WHO halves cholera vaccine dosage as cases rise worldwide

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WHO halves cholera vaccine dosage as cases rise worldwide
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As Nigeria battles the outbreak of cholera in some parts of the country, World Health Organisation (WHO) on Wednesday suspended the two-dose vaccination regimen used in the cholera outbreak response following a strained global supply of the vaccines.

In a press statement, WHO said since January this year, 29 countries have reported cholera cases, including Haiti, Malawi, and Syria which are facing large outbreaks. In comparison, in the previous 5 years, fewer than 20 countries on average reported outbreaks.

“The one-dose strategy has proven to be effective to respond to outbreaks, even though evidence on the exact duration of protection is limited, and protection appears to be much lower in children. With a two-dose regimen, when the second dose is administrated within 6 months of the first, immunity against infection lasts for 3 years.

“The current supply of cholera vaccines is extremely limited. Its use for emergency response is coordinated by the ICG which manages the global stockpile of oral cholera vaccines. Of the total 36 million doses forecast to be produced in 2022, 24 million have already been shipped for preventive and reactive campaigns and an additional 8 million doses were approved by the ICG for the second round for emergency vaccination in 4 countries, illustrating the dire shortage of the vaccine.

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