New research shows that a treatment plan based on novel combination of low doses of three anti-hypertensive drugs in a single pill - known as GMRx2 - was superior to a high-quality standard care treatment plan at lowering blood pressure in patients with uncontrolled hypertension.
George Institute for Global Health Sep 1 2024
After 6 months treatment, home systolic blood pressure was 31mmHg lower in the GMRx2 group compared to 26 mmHg lower with standard care – the 5.8 mmHg difference was highly clinically and statistically significant. Existing evidence shows that with every 5 mmHg reduction in systolic blood pressure there is a 10% reduction in major cardiovascular events such as stroke, heart attack and heart failure.
In low-income countries fewer than one in four treated people achieve blood pressure control and in high-income settings it is only between 50% and 70%," added Prof Ojji, "so to see rates of over 80% in just one month is impressive." GMRx2 is the leading drug candidate of George Medicines, a late-stage, biopharmaceutical company addressing significant unmet need in the treatment of cardiometabolic disease, established to commercialize the research of The George Institute for Global Health. Earlier this month, GMRx2 was submitted to the US Food and Drug Administration for the treatment of hypertension.
Blood Pressure Amlodipine Cardiology Cardiovascular Disease Clinical Trial Drugs Global Health Heart Heart Attack Heart Failure Placebo Research Stroke
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