Initiating drug treatment for ADHD is linked to significantly lower all-cause mortality, particularly for deaths caused by accidental poisoning, suicide, or accidental injury.
"ADHD medication may reduce the risk of unnatural-cause mortality by alleviating the core symptoms of ADHD and its psychiatric comorbidities, leading to improved impulse control and decision-making, ultimately reducing the occurrence of fatal events, in particular among those due to accidental poisoning," the investigators, with first author Lin Li, PhD, Karolinska Institutet in Stockholm, Sweden, wrote.
Using national Swedish registries, the researchers examined whether initiation of medications to treat ADHD was associated with mortality in children, youth, and adults. They followed the cohort of 148,578 individuals from ADHD diagnosis until death, emigration, 2 years post-baseline, or to the end of 2020, whichever came first. In sensitivity and subgroup analyses, 5-year mortality as well as sex- and age-specific associations were also assessed.A total of 630 participants with ADHD died during the shorter 2-year follow-up, and 1400 died during the 5-year follow-up period.
The study shows an association and not a causal relationship, the investigators noted, pointing out that there are no data on lifestyle factors, which may have contributed to these correlations., Francis Levin, MD; Mariely Hernadez, PhD; and John Mariani, MD; Department of Psychiatry, Columbia University, New York, NY, noted that the study supports previous research that appropriate prescribing of ADHD medications can significantly reduce mortality.
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