Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled 'NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway' that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.
Frontiers JournalsAug 2 2024 Cong Peng et al., at Department of Dermatology , Xiangya Hospital , Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway " that investigates the role of Neuropilin and tolloid-like 2 in melanoma, a deadly form of skin cancer . The research explores how NETO2, a membrane protein, influences the progression of melanoma through the Ca²⁺/CaMKII signaling pathway .
The researchers hypothesize that NETO2 is involved in melanoma progression by activating the Ca²⁺-dependent CaMKII/CREB pathway. To test this, they demonstrate that NETO2 is overexpressed in melanoma and associated with the survival rate of melanoma patients. They show that NETO2 promotes melanoma cell proliferation and migration, and increases intracellular calcium concentration, leading to increased phosphorylation of CaMKII and CREB.
Signaling Pathway Calcium Cancer Cell Cell Proliferation CREB Dermatology Hospital Intracellular Membrane Proliferation Protein Research Skin Skin Cancer
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