Stirring the Primordial Soup: Unveiling Secrets of Early Life With Synthetic Models

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Stirring the Primordial Soup: Unveiling Secrets of Early Life With Synthetic Models
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Science, Space and Technology News 2024

Researchers from the Okinawa Institute of Science and Technology created synthetic droplets to study chemotaxis, mimicking cellular movement by responding to chemical gradients which could explain early life movement and inspire future technologies. Their findings, using droplets that migrate toward each other due to changes in pH and surface tension, contribute to understanding fundamental biological processes and the potential development of new biotechnological applications.

How do cells move around inside these extremely complicated systems? How do they know where to go? And how did they get so complicated to begin with? Simple yet profound questions like these are at the heart of curiosity-driven basic research, which focuses on the fundamental principles of natural phenomena. An important example is the process by which cells or organisms move in response to chemical signals in their environment, also known as chemotaxis.

Numerical models showing what happens when the halos of two synthetic droplets interact. pH in the space between the droplets is higher , which causes the droplets to migrate towards each other while keeping their spherical shape, as pH is lower within the droplets, until they meet and merge. Larger droplets attract smaller droplets.

How do the droplets move, and what determines their direction? Each green droplet is densely packed with proteins as well as an enzyme that increases the pH-value within and around the droplet, which may lead to the answer to these questions. Credit: OIST The research also points ahead in time, providing leads on new technology. “One example is the creation of responsive materials inspired by biology,” suggests Alessandro Bevilacqua. “We have shown how simple droplets can migrate thanks to a chemical gradient. A future application of this could be technologies that sense or react to chemical gradients, for example in micro-robotics or drug delivery.

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