Researchers have isolated 18 bacterial strains from stool from healthy people that could potentially be a more effective treatment for antibiotic-resistant gut infections.
Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections The team found that these strains suppress the growth of Enterobacteriaceae and alleviate inflammation in the guts of mice by competing with the harmful bacteria for carbohydrates and preventing them from colonizing the intestine.
"Despite two decades of microbiome research, we are just beginning to understand how to define health-promoting features of the gut microbiome," said Marie-Madlen Pust, a computational postdoctoral researcher at Broad and co-first author on the paper. Pust is in the lab of Xavier, who is co-director of its Infectious Disease and Microbiome Program. Xavier is the Kurt J. Isselbacher Professor of Medicine at Harvard Medical School; director of the Center for Computational and Integrative Biology at Massachusetts General Hospital ; and co-director of the Center for Microbiome Informatics and Therapeutics at MIT.
The 18 strains also did not disrupt the growth of other healthy bacteria in animals with gut microbes from patients with Crohn's disease and ulcerative colitis, further underscoring their therapeutic promise. Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse ...
Gastrointestinal Problems Infectious Diseases Today's Healthcare Microbes And More Bacteria Microbiology Mice
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