Research expands understanding of vaccine-induced immune thrombocytopenia and thrombosis

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Research expands understanding of vaccine-induced immune thrombocytopenia and thrombosis
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New research led by Flinders University and international experts is expanding understanding of vaccine-induced immune thrombocytopenia and thrombosis (known as VITT).

May 16 2024Flinders University New research led by Flinders University and international experts is expanding understanding of vaccine-induced immune thrombocytopenia and thrombosis .

VITT was found to be caused by an unusually dangerous blood autoantibody directed against a protein termed platelet factor 4 . Flinders University researchers Dr Jing Jing Wang and Flinders Professor Tom Gordon, Head of Immunology at SA Pathology in South Australia, led a previous study in 2022 which cracked the molecular code of the PF4 antibody and identified a genetic risk factor related to an antibody gene termed IGLV3.21*02.

The research will also have implications for improving vaccine development, says Flinders University researcher Dr Wang, first author on the new article to be published in the eminent New England Journal of Medicine on Thursday .

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