The 2023 Nobel Prize in physiology or medicine will go to Katalin Karikó and Drew Weissman for their discovery that modifying mRNA—a form of genetic material your body uses to produce proteins—could reduce unwanted inflammatory responses and allow it to be delivered into cells. While the impact of their findings may not have been apparent at the time of their breakthrough over a decade ago, their work paved the way for the development of the Pfizer-BioNTech and Moderna COVID-19 vaccines, as well as many other therapeutic applications currently in development.
—a form of genetic material your body uses to produce proteins—could reduce unwanted inflammatory responses and allow it to be delivered into cells. While the impact of their findings may not have been apparent at the time of their breakthrough over a decade ago, their work paved the way for the development of the Pfizer-BioNTech and Moderna COVID-19 vaccines, as well as many other therapeutic applications currently in development.
This work fed into more questions that ushered in the age of antibiotics. The 1952 Nobel Prize in physiology or medicine was awarded to Selman Waksman for his A good example of this was when the human genome was first sequenced in the early 2000s. A lot of people thought that having access to the full sequence would lead to treatments and cures for many different diseases. But that has not been the case, because there are many nuances to translating basic research to the clinic. What works in a cell or an animal might not translate into people. There are many steps and layers in the process to get there.
In the short term, the worth of basic research can be hard to see. But in the long term, history has shown that a lot of what we take for granted now, such as common medical equipment like
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