Antidepressants, the gold standard treatment for depression, don’t work for many people. Will psilocybin be an alternative?
The matchup: Two doses of psilocybin, the active ingredient in “magic mushrooms,” against a six-week course of the popular antidepressant escitalopram, often sold as Lexapro or Cipralex. Escitalopram is one of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs. The projected winner: The drug that produces the best outcome at six months in the battle against depression, which affects more than 300 million people worldwide.
“They can look through a door to a different way of thinking, and they can then walk through the door afterwards.” Integrating those new insights into daily behavior that lasts, however, is the key to long-term success in fighting depression, experts say. That’s why studies on psilocybin have used trained therapists during the hallucinogenic trip, along with therapy sessions before and after the experience.
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