Nature research paper: Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
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The SARS-CoV-2 B.1.1.529 variant contains 15 mutations on the receptor-binding domain . How Omicron would evade RBD neutralizing antibodies requires immediate investigation. Here, we used high-throughput yeast display screeningto determine the RBD escaping mutation profiles for 247 human anti-RBD NAbs and showed that the NAbs could be unsupervised clustered into six epitope groups , which is highly concordant with knowledge-based structural classifications.
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