Scientists have long believed that a newborn's immune system was an immature version of an adult's, but new research from Cornell University shows that newborns' T cells – white blood cells that protect from disease – outperform those of adults at fighting off numerous infections.
Feb 24 2024Cornell University Scientists have long believed that a newborn's immune system was an immature version of an adult's, but new research from Cornell University shows that newborns' T cells – white blood cells that protect from disease – outperform those of adults at fighting off numerous infections.
This discovery was described in a paper published in Science Immunology on Feb. 23, co-led by Brian Rudd, associate professor of microbiology and immunology, and Andrew Grimson, professor of molecular biology and genetics. Interested in understanding these age-related differences, Rudd and Grimson discovered that newborn T cells are not deficient: Instead, they are involved in a part of the immune system that does not require antigen recognition: the innate arm of the immune system.
"We know that neonatal T cells don't protect as well as adult T cells against repeat infections with the same pathogen. But neonatal T cells actually have an enhanced ability to protect the host against early stages of an initial infection," Rudd said. "So, it is not possible to say adult T cells are better than neonatal T cells or neonatal T cells are better than adult T cells. They just have different functions.
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