Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins.
Tokyo Metropolitan UniversityJul 28 2024 The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression , promising applications to treatments of serious muscle diseases.
A team from Tokyo Metropolitan University led by Professor Shoichiro Asayama have been studying the use of polyions, polymers with an electric charge, to carry plasmid DNA into cells. Plasmid DNA can be transcribed to messenger RNA or translated into proteins, making them a versatile vehicle for therapies. They also happen to be negatively charged polymers which can bind to positively charged polyions.
In preliminary experiments, they found that their new compound had a layer of bound water molecules in solution which might render them bioinert. Mixed with pDNA, a method used to separate DNA compounds by length was used to show that pDNA can successfully complex with CA-PVIm. Other measurements also demonstrated that the complex hierarchical structure of the pDNA was preserved.
Muscle Compound DNA Gene Gene Expression Ion Molecule Plasmid Polymers RNA
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