While research has uncovered many details about how blood cells function within bone marrow, the work of other cells existing in that space remained a relative mystery.
University of PennsylvaniaJun 18 2024 Now, researchers from the Perelman School of Medicine at the University of Pennsylvania and Children 's Hospital of Philadelphia have published a " bone marrow atlas" in Cell that provides a first-of-its-kind, full view of all the cells existing within it, offering a better understanding of both healthy and diseased blood production.
Bone marrow mostly consists of blood cells, however, a small percentage of non-blood cells may play an important role in conditions such as leukemia, other blood cancers, or bone marrow failure syndromes. Through the team's efforts, researchers and doctors now have a much clearer picture of the functions of the rarer, but key, cells in the bone marrow such as stromal cells, bone cells, and endothelial cells.
Through work aided by both an artificial intelligence technique called machine learning and painstaking hand-labeling of individual cells, the team was able to discern both that healthy bone marrow has very distinct spatial organization and stromal cells are more closely associated with blood-producing cells than previously understood.
"When applied to leukemia patient samples, these techniques identify the expansion of mesenchymal cells, a type of rare non-blood cell, at the cancer cell site in the bone marrow," said the study's co-senior author Ling Qin, PhD, a professor of Orthopedic Surgery at Penn Medicine. "This reveals a potential new direction for future disease treatment."
Bone Marrow Blood Cancer Cell Children Gene Gene Expression Hospital Leukemia Medicine Pediatrics Research
Nigeria Latest News, Nigeria Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers develop new method to remove blood cells in leukemia patients while building new blood systemResearchers have developed an approach to 'deleting' a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports on the promising results obtained in animal experiments and with human cells in the laboratory.
Read more »
Portal connecting Dublin and New York 'reawakens' under new restrictions after 'inappropriate behaviour'The interactive artwork is back up and running again - but measures have been put in place to to crack down on 'inappropriate behaviour' which led to its temporary shutdown.
Read more »
McDonald's trialling new Happy Meal menu in Lancashire with four new itemsThe new Happy Meal items will be available for a three-month trial period from May 29
Read more »
Macron heads to New Caledonia as Australia and New Zealand evacuate citizens after deadly riotsSix people, including two police officers, have been killed in the violence which erupted after protests over voting reforms being pushed through by Mr Macron's government.
Read more »
Teresa Giudice's daughter Milania, 18, crashes her BRAND NEW $60K Mercedes in New JerseyTeresa Giudice and her daughters Gia, Milania and Audriana team up with clothing brand Shein for collaboration. The Giudice girls modeled several daring looks for the collection.
Read more »
Teresa Giudice's daughter Milania, 18, crashes her BRAND NEW $60K Mercedes in New JerseyTeresa Giudice and her daughters Gia, Milania and Audriana team up with clothing brand Shein for collaboration. The Giudice girls modeled several daring looks for the collection.
Read more »