“People have done studies before showing that sometimes cannabis works against cancer, and sometimes, it does not.” Nigeria CureForCancer
Several researches have shown that as people age, the risk of developing pancreatic cancer goes up. Most patients are older than 45, and nearly 90 per cent are older than 55. The average age at diagnosis is 71.Men have a slightly higher likelihood of developing pancreatic cancer than women, which may partly result from increased tobacco use in men. In the past, when men more commonly smoked than women, the gender gap was wider.
Scientists at the Harvard University, United States tested the effects of marijuana-derived compounds called flavonoids on pancreatic cancer cells in petri dishes and on animals with the disease. According to the research published in journal Frontiers of Oncology last month, flavonoids treatment killed all the tumor cells in 70 percent of mice with pancreatic cancer that the researchers tested for the study.
Meanwhile, cannabinoids are already used and studied for treating the unpleasant side effects of standard cancer therapies like chemo and radiation. Marijuana can be prescribed for medical uses in more than half of US states, where it is used to combat anxiety, aggression and sleeping problems. Researchers are also looking into whether it could help people with autism, eczema or psoriasis.Ngwa and his team first separated out many parts of the cannabis plant and ran preliminary tests to see which parts showed the most ‘activity’ against tumours.
Their other hypothesis involves a process call “apoptosis.” “It kills cancer cells, but it does it in such a way that it exposes the camouflage of the cancer cells that hides them from T-cells.” It is possible that these processes mean that the immune system would “remember” the cancer if it came back, too. But do these promising results mean that cancer patients should be turning to cannabis, its oils and extracts? “We get a lot of patients who are asking that question,” said Ngwa.
According to a study published in Asian Pacific Journal of Tropical Biomedicine titled “A review on therapeutic potential of Nigella sativa: A miracle herb”, the plant has been widely used as antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, appetite stimulant, analgesics, anti-bacterial and in skin disorders.
Arafat and her co-workers also found that thymoquinone caused “epigenetic” changes in pancreatic cancer cells, modifying the cells’ Deoxy ribonucleic Acid /genetic material. She explained that these changes involve adding acetyl groups to the DNA structure, specifically to blocks of proteins called histones. This “acetylation” process can be important for genes to be read and translated into proteins. In this case, it could involve the genes that are key to initiating programmed cell death.
Psorospermin, a natural product isolated from the stembark and roots of the African plant Psorospermum febrifugum, had the activity against drug-resistant leukemia lines and Human Immuno-deficiency Virus /Acquired Immune Deficiency Syndrome -related lymphoma. Fellows et al. showed that psorospermin had the same effect as gemcitabine in inhibiting the growth of tumor in vivo in the MiaPaCa pancreatic xenograft model.
Isothiocyanate sulforaphane is a natural compound present in broccoli and other cruciferous vegetables with high concentration. Kallifatidis et al. showed that SF increased the effectiveness of cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.
Zyflamend is a polyherbal formulation comprised of ten standardized and concentrated herbal extracts . Kunnumakkara et al. showed Zyflamend in combination with gemcitabine synergically inhibited the growth of human pancreatic cells in vitro and in vivo by inhibiting NF-κB signaling pathways. MK615, called Ume in Japanese, is a sticky extract from Japanese apricot, which has been used to treat intestinal disorders for many years as an antipyretic and an anti-inflammatory agent. Hattori et al.
Ding et al. showed the combination of that wogonin, a naturally occurring flavone, with the structurally related natural flavones apigenin and chrysin could enhance TRAIL-mediated apoptosis in pancreatic carcinoma CaPan-1 cells, by upregulation of TRAIL receptor 2 and transcriptional downregulation of c-FLIP .
The anticancer effect has been seen in a few clinical trials, mainly as a native chemoprevention agent in colon and pancreatic cancer, cervical neoplasia, and Barrett’s metaplasia . Although curcumin may potentiate the antitumor effect of gemcitabine by intervening with several intracellular signal transduction pathways in pancreatic cancer cells in vitro and in vivo, Epelbaum et al.
According to the researchers from the Department of Allergy, Asthma and Immunology, Rutgers New Jersey Medical School, Newark, NJ, US, a variety of relatively safe and inexpensive treatment options that have shown success in preclinical models and/or retrospective studies are currently available. Patients require their physicians to provide therapeutic guidance and assistance in obtaining and administrating these various therapies.
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