Familial loss is linked to accelerated biological aging, especially when losses occur in adulthood, highlighting the long-term health impacts of bereavement.
By Tarun Sai LomteReviewed by Susha Cheriyedath, M.Sc.Jul 30 2024 In a recent study published in the journal JAMA Network Open, researchers in the United States evaluated the associations between the loss of a family member and biological aging.
Participants with blood samples who reported loss were included. Between 2018 and 2024, the team profiled and constructed clocks using whole-blood DNA from 4,700 wave 5 participants. They calculated four biological clocks: DunedinPACE, Horvath, PhenoAge, and GrimAge. DunedinPACE measures the pace of aging, while the other three measure epigenetic age acceleration.
Findings Overall, the sample included 3,963 participants aged 38.36, on average, at the fifth wave. Around 50.3% of subjects were males, 72.5% were White, and 16% were Black. Approximately 40% of participants experienced at least one loss. Parental loss was the most common loss, and most losses occurred during adulthood.
Blood Cardiometabolic Compound DNA Mental Health Mortality
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