Hope as race for Coronavirus vaccine hots up
has directed appropriate agencies to embark on validation of an herbal mixture touted as cure for coronavirus. Although the World Health Organisation has repeatedly said that it has not approved any drug or vaccine for treating coronavirus, many have hailed COVID-Organics from Madagascar as Africa’s response to the global pandemic that has no cure yet.
Pfizer said it is working with German pharmaceutical company BioNTech on the candidate vaccine, dubbed BNT162. The company first tested it in Germany last month on 12 healthy adults. The two companies say they plan to test the candidate vaccine on 360 healthy volunteers in the United States. BNT162 is a messenger RNA vaccine that instructs cells to make a specific piece of protein to match what’s on SARS-CoV-2’s spike protein.
Moderna’s vaccine candidate, which was developed in collaboration with scientists at the National Institutes of Allergy and Infectious Disease, is made out of messenger RNA; hence the phrase mRNA in the vaccine’s name. This molecule is responsible for carrying the genetic recipes for making different proteins to a cell’s protein production factories.
At the University of Pennsylvania, researchers are also testing the safety of another genetic vaccine, produced by the nearby biotech company Inovio. Codenamed INO-4800, the vaccine is made out of synthetic DNA instead of RNA, though the principle is the same. Packaged into the DNA is a section of the SARS-CoV-2 spike protein. Inovio is testing two doses of INO-4800 in 40 healthy volunteers split between UPenn and the Center for Pharmaceutical Research in Kansas City, Missouri.
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