Genetic analysis links GERD to IPF MedTwitter
) and were clumped by linkage disequilibrium . Evidence from analysis associating each comorbidity with IPF was categorized as either convincing, suggestive, or weak. Follow-up studies examined the causal effects of measured lung and thyroid variables on IPF and IPF effects on blood pressure variables.The bidirectional MR and follow-up analysis revealed"convincing evidence" of causal relationships between IPF and two of the evaluated 22 comorbidities.
This contrasted with VTE: On the basis of bidirectional MR analysis, the researchers suggest that VTE was more likely to be a cause rather than a consequence of IPF.The primary strengths of the study was the ability of MR design to enhance causal inference, particularly when large cohorts for perspective investigations would be inherently difficult to obtain.
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