Sarcopenia also predicted exacerbations in multivariate analysis.
C-reactive protein levels and eosinophil-to-platelet ratio are significant independent predictors of adverse events in patients with chronic obstructive pulmonary disease hospitalized with acute exacerbations.Known risk factors for COPD exacerbations do not fully explain the variation in susceptibility among patients; data on potential biomarkers as predictors of COPD exacerbations are limited.
In a prospective, observational study at a single center, the researchers examined clinical and lab data including serum CRP levels, EPR, sarcopenia, lung function, nutrition, and frailty. The study population included 200 adults older than 40 years with COPD who were hospitalized for acute exacerbations; 50 experienced adverse events.Both elevated CRP and low EPR were significant predictors of adverse events in adjusted analysis in patients with COPD exacerbations .
In a multivariate analysis, EPR and CRP, as well as sarcopenia, were significantly associated with adverse events . COPD symptom scores, frailty, and malnutrition showed predictive value in bivariate but not multivariate analysis."Screening for these biomarkers on admission could help identify high-risk patients who need more aggressive monitoring and treatment," the researchers wrote in their discussion.The lead author on the study was Rohankumar Gandhi, MD, of Guru Gobind Singh Government Hospital, Jamnagar, India.
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