Individuals with compromised immunity and persistent COVID-19 infections can harbor drug-resistant variants of the SARS-CoV-2 virus, which have the potential to spread to the general population found researchers at Weill Cornell Medicine, the College of Veterinary Medicine at Cornell University and the National Institutes of Health's (NIH)...
Weill Cornell Medicine Sep 18 2024 Individuals with compromised immunity and persistent COVID-19 infections can harbor drug-resistant variants of the SARS -CoV-2 virus, which have the potential to spread to the general population found researchers at Weill Cornell Medicine , the College of Veterinary Medicine at Cornell University and the National Institutes of Health's National Institute of Allergy and Infectious Diseases .
The risk in emerging mutations is the possibility of transmitting these new resistant variants to the general population with fewer viable treatment options available. We have to come up with better treatments for immunocompromised patients and consider investigating combinations of therapies." Unique challenges in treating persistent COVID infections While people with working immune systems can typically clear SARS-CoV-2 within days, those who are immunocompromised may continue to harbor and shed the virus for longer, even without symptoms. They also often receive multiple antiviral treatments over time, which may lead to the emergence of drug-resistant variants.
Combination therapies may be the answer The researchers found that when they grew the isolated virus in lab cell cultures, two drugs simultaneously were effective in clearing the drug-resistant strain. "These findings indicate that combination therapy may be a better option to treat COVID-19 in highly vulnerable immunocompromised patients," said co-senior author Dr.
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