A new tool for monitoring immune health patterns over time has revealed how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.
University of Pennsylvania School of Medicine Aug 29 2024 Findings from the use of the new tool, developed by researchers at the University of Pennsylvania Perelman School of Medicine and Penn Medicine 's Abramson Cancer Center , were published today in Cancer Cell .
We found that after every infusion, you have a new immune response, with a new group of T cells coming in to fight the cancer. Think about these T cells like an army: for many cancer patients, even when they have tumors growing, experienced T cell fighters are trying to slow down the advance of the enemy cancer cells.
Previous research has shown that exhausted T cells, the elite fighters, come from a source called progenitor cells. Anti-PD-1 immunotherapy taps into this source and eventually depletes the supply. In the current study, the researchers discovered that that anti-CTLA-4 therapy complements PD-1 checkpoint inhibitors by replenishing the supply of progenitor-exhausted T cells, adding more elite fighters to the ranks.
Immunotherapy Blood Cancer Immunotherapy Cell CTLA-4 Drugs Hospital Immune Response Medicine Melanoma Research
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