An 'unconventional' immune response now identified by scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) is a potential new pathway for developing new vaccines for tuberculosis (TB), according to a new publication.
Hackensack Meridian HealthJul 15 2024 An "unconventional" immune response now identified by scientists from the Hackensack Meridian Center for Discovery and Innovation is a potential new pathway for developing new vaccines for tuberculosis , according to a new publication.
"Our results indicate that B cells skew their immune landscape toward MZB cells to execute regulatory functions against TB, emphasizing the importance of antibody-independent mechanisms of B cells for controlling infectious disease, a previously neglected mechanism," write the authors. Through detailed tracking of this shift, the MZB cells showed higher activity and memory-like phenotype expression in response to the infection. In turn, that shaped cytokine patterns and then boosted cell-mediated immunity.
Cytokine Immune Response Immunity Ph Research Tuberculosis Vaccine
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