Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase (JAK) inhibitors – drugs that treat chronic inflammation – could help.
American Association for the Advancement of Science Jun 20 2024 Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase inhibitors – drugs that treat chronic inflammation – could help. In two separate clinical studies, researchers found that adding JAK inhibitors did improve patients' responses to cancer checkpoint inhibitor immunotherapies.
"Aside from the exciting findings of the early phase trials reported by , they provide a great deal of data with complex analyses of immune responses," write Massimo Gadina and John O'Shea in a related Perspective. "It will be exciting to see how such sophisticated data might be used in the clinic and to inform research.
In two independent clinical studies, researchers investigated whether using JAK inhibitors or jakinibs, which prevent inflammation from inside cells, could improve antitumor responses of anti-PD-1 ICI immunotherapy in cancer patients. Divij Mathew and colleagues conducted a phase II clinical trial to investigate the use of the JAK1 inhibitor itacitinib in combination with the anti-PD-1 ICI pembrolizumab as a first-line treatment for metastatic non-small cell lung cancer . Mathew et al.
Related StoriesScience Senior Editor, Priscilla Kelly, commented: "These two clinical trials are notable because they pave the way for a new possible therapeutic strategy. The researchers find that in two different cancer types, combining Janus kinase inhibitors with checkpoint inhibitor immunotherapy results in better clinical responses in patients with metastatic non-small cell lung cancer and those with relapsed or refractory Hodgkin lymphoma.
Immunotherapy Cancer Immunotherapy Cell Chronic Clinical Trial Drugs Hodgkin Lymphoma Inflammation Kinase Lung Cancer Lymphoma Non-Small Cell Lung Cancer Small Cell Lung Cancer
Nigeria Latest News, Nigeria Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Combining human olfactory receptors with artificial organic synapses and a neural network to sniff out cancerA team of chemical and biological engineers at Seoul National University in the Republic of Korea has developed a proof-of-concept device that could one day lead to the creation of an artificial nose.
Read more »
Combining biomedical data from breast cancer patients could lead to 'groundbreaking discoveries'Studying combined data from the UK Biobank, a unique record of patient information from more than half a million Britons, could help make 'groundbreaking discoveries' in the understanding and treatment of breast cancer, say researchers.
Read more »
Combining donepezil and memantine extends lives of Alzheimer's patients, study findsAlzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally.
Read more »
Six distinct types of depression identified in study combining brain imaging with machine learningIn the not-too-distant future, a screening assessment for depression could include a quick brain scan to identify the best treatment.
Read more »
Tartan Army chief creates unique Scotland Lederhosen outfit to wear in GermanyChris ‘Gibbo’ Gibson, 48, will rock a completely new look when he heads to the Euros, combining the traditional Bavarian outfit with the dark blue of the national team.
Read more »
Combination therapy shows promise in subset of breast cancersCombining two cancer drugs may be a promising treatment for advanced metastatic breast cancer, according to the results of a clinical trial published in JAMA Oncology.
Read more »