A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI.
Keck School of Medicine of USCSep 5 2024 A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI. With limited treatment options, AKI frequently progresses to chronic kidney disease , which affects more than 1 in 7 U.S. adults-;an estimated 37 million people.
"Dr. Cai's seqFISH technology provides unprecedented insight into the cellular interplay in the kidney following injury," said McMahon, who is the W.M. Keck Provost and University Professor of Stem Cell Biology and Regenerative Medicine at USC and will join the faculty of Caltech in October. "A better understanding of kidney injury is needed to identify targets for preventing the progression to chronic kidney disease.
In the kidney's outermost layer, the scientists identified a likely pathological microenvironment, which they dubbed "ME-5." This microenvironment contained a type of kidney cell particularly vulnerable to injury, known as a proximal tubule cell or PT. The scientists also identified another important injury-associated microenvironment, which they named "ME-16," featuring aggregations of various immune cell types called tertiary lymphoid structures that are known to contribute to chronic inflammation. Rather than being confined to a specific region of the kidney, ME-16 was distributed throughout the injured organ.
Kidney Biotherapeutics Cell Chronic Chronic Kidney Disease Fibrosis Genes Genomics Inflammation Kidney Disease Kidney Failure Medicine Research Technology
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