A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling.
University of Texas Health Science Center at San AntonioJul 5 2024 Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human immune system and a human-like gut microbiome that is capable of mounting specific antibody responses.
Mice are widely used in biological and biomedical research because they are small, easy to handle, share many immune elements and biological properties with humans and are easily genetically modified. Many of the more than the 1,600 immune response mouse genes, however, are incongruent with their human equivalents, resulting in divergencies or deficiencies of mice as predictors of human immune responses.
The resulting humanized mice, called TruHuX , possess a fully developed and fully functional human immune system, including lymph nodes, germinal centers, thymus human epithelial cells, human T and B lymphocytes, memory B lymphocytes, and plasma cells making highly specific antibody and autoantibodies identical to those of humans.
As prior research on the effect of estrogen and the immune system is sparse, Casali hopes this discovery prompts further research into the topic.
Mouse Model Antibodies Antibody Bacteria Cancer Cell Covid-19 Disease Modeling Epigenetics Estrogen Genetics HIV Immune Response Immunology Immunotherapy In Vivo Medicine Microbiology Microbiome Research Salmonella SARS SARS-Cov-2 Stem Cells Vaccine
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