A brain network involved in reward processing and attention to stimuli is markedly bigger in people with depression and can be detected in children before depression onset.
Researchers have discovered that a brain network involved in reward processing and attention to stimuli is markedly bigger in people with depression, remains stable over time, is unaffected by mood changes, and can be detected in children before onset of depression symptoms.
"We leveraged our large longitudinal datasets — with many hours of functional MRI scanning per subject — to construct individual-specific maps of functional brain networks in each patient using precision functional mapping, instead of relying on group average," Lynch said. In four of the six individuals, the salience network was expanded more than twofold, outside the range observed in all 37 healthy controls. On average, the salience network occupied 73% more of the cortical surface relative to the average in healthy controls.
"These observations led us to propose that instead of driving changes in depressive symptoms over time, salience network expansion may be a stable marker of risk for developing depression," the study team wrote. Lakhan, who wasn't involved in this research, said identifying the expansion of the frontostriatal salience network in individuals with depression opens new avenues for developing novel therapeutics.
"Drugs that modulate synaptic plasticity or network connectivity might be developed to reverse or mitigate these neural changes. The findings also support the use of longitudinal monitoring to predict and preempt symptom emergence, improving outcomes through timely intervention. This research paves the way for more personalized, precise, and proactive approaches in treating depression," Lakhan concluded.
Brain Major Depression Major Depressive Disorder Unipolar Depression Clinical Depression MDD Brain Mapping Brain Stimulation Children Child Childhood Pediatrics Kids Deep Brain Stimulation DBS - Deep Brain Stimulation Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Functional Mri Functional Magnetic Resonance Imaging
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