Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.
Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children's Hospital of Philadelphia demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.
"We suspected that we may be able to disrupt SARS-CoV-2's ability to cause disease by reducing the amount of mROS, thus blocking the metabolic shift important for viral synthesis," said the study's first author Joseph W. Guarnieri, PhD, a postdoctoral fellow in the Wallace lab at the Center for Mitochondrial and Epigenomic Medicine at CHOP.
This study was supported by Department of Defense W81XWH-21-1-0128 grant PR202887 and The Bill and Melinda Gates Foundation grant INV-04672. Additional grant support was provided by National Institutes of Health grants 1R01CA259635, 1R01AG078814 and R01NS114656 and Foerderer grant 00003469.Joseph W. Guarnieri, Timothy Lie, Yentli E. Soto Albrecht, Peter Hewin, Kellie A. Jurado, Gabrielle A. Widjaja, Yi Zhu, Meagan J. McManus, Todd J.
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