Science, Space and Technology News 2024
A pro-regenerative therapy developed by KAUST researchers could have many applications, from corneal repair to skin-protective cosmetics. Credit: 2024 KAUST, a transposable element in the human genome, plays a crucial role in bone repair. This breakthrough, challenging the old view of such elements as ‘junkApproximately half of the human genome consists of DNA fragments derived from ancient viruses.
Firstly, the team conducted sequencing experiments on mice with bone fractures and found that TEs, especially LINE-1 RNA, were upregulated for a short period of time following fracture. “We added synthetic LINE-1 RNA to these cell cultures, and the results were surprisingly clear,” says Mangiavacchi. “Osteoblasts treated with LINE-1 RNA displayed a distinctive phenotype where the bone matrix formed abundantly and quickly. Crucially, cells derived from osteoporotic patients were rescued by the LINE-1 RNA treatment.”
This discovery is protected by two patents, one licensed to biotech company Altos Labs in California, and the other to the start-up company RepeatEra, founded by Orlando and Mangiavacchi, to take their pro-regenerative therapy to clinical trials.
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